杨 磊1，2，罗婧菱1，2，李浩辰3*
（1.广西中医药大学第一附属医院，南宁530000；2 .广西高校中医临床研究重点实验室，南宁530000；3.天津国际旅行卫生保健中心（天津海关口岸门诊部），天津300000）
摘要：随着刀豆蛋白A（Concanavalin A，ConA）的纯化技术和结构性质的深入研究，其应用领域不断扩大。ConA在制备各类肝损伤实验动物模型方面应用较多，对肝脏疾病的诊断与治疗起到了关键作用。在癌症研究中，ConA展现了抗肿瘤能力，能够通过促进细胞凋亡、抑制细胞增殖及阻断血管生成等多种机制，抑制肿瘤细胞的生长和扩散。由于其在临床上的抗癌效果令人瞩目，因此包含ConA的抗癌药物已被广泛用于治疗。此外，ConA在增强人体免疫力方面也显示出了重要的作用，特别是在激活T淋巴细胞方面。它不仅在生物学和生物化学研究中被广泛应用，还在糖蛋白分子的鉴定、临床诊断以及化学和医学研究等领域发挥着重要作用。该文旨在全面回顾ConA目前的研究进展，并对其未来发展方向进行展望。
关键词：刀豆蛋白A；肿瘤；临床诊断；免疫
中图分类号：Q946.1 文献标识码：A 文章编号：1674-506X（2025）01-0125-0007
Research Progress on Biological Activity and Application of Concanavalin A
YANG Lei1，2，LUO Jingling1，2，LI Haochen3*
（1.First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530000，China；2.Key Laboratory of Chinese Medicine Clinical Research，Education Department of Guangxi Zhuang Autonomous Region，Nanning 530000，China；3.Tianjin International Travel Health Care Center（Tianjin Customs Port Outpatient Department），Tianjin 300000，China）
Abstract： With the in-depth study of concanavalin A (short for ConA) purification methods and its structural properties, its application scope has been continuously expanding. ConA is used to create various experimental animal models of liver injury, which plays a crucial role in the diagnosis and treatment of liver diseases. In the field of cancer research, ConA has shown anti-tumor ability through multiple mechanisms like inducing cell apoptosis, inhibiting cell proliferation, and suppressing angiogenesis, effectively restraining the growth and metastasis of cancer cells. Its clinical anti-cancer effects are remarkable, and anti-cancer drugs with ConA have been widely used in clinical treatment. In addition, ConA plays an important role in enhancing human immunity especially in activating the T lymphocytes. ConA is widely used in the fields of biology and biochemistry research. Additionally, ConA has been applied in glycoprotein molecule identification, clinical diagnosis, chemistry, medicine, and other research areas. This article provides a comprehensive review of the current research progress on ConA and outlines its future development directions.
Keywords：concanavalin A；tumor；clinical diagnosis；immunology
doi：10.3969/j.issn.1674-506X.2025.01-017
